All-In with Chamath, Jason, Sacks & Friedberg

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  Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like

  Published Mar 26, 2026

  Bryan Johnson

  (0:00) David Friedberg intros Bryan Johnson (0:54) Why Bryan Johnson did 5-MeO-DMT (12:56) What brain scans actually show (18:36) Psychosis, bad trips, and life-altering decisions (26:23) The next frontier: organoids and gene therapy (33:26) GLP-1s, abundance, and human optimization (35:35) The longevity drug nobody's talking about? Thanks to our partner for making this happen! The Pod by Eight Sleep cools your bed to 55°F and uses Autopilot to optimize your sleep, all night. Use code ALLIN at h